hopkins medicine klinefelter

Philip Jordan, PhD (Biochemistry and Molecular Biology)

Email: pjordan8@jhu.edu
Phone: 410-614-4773

Research in the Jordan laboratory focuses on understanding the molecular mechanisms regulating DNA repair, chromosome segregation and cell cycle progression. Their lab studies the importance of Structural Maintenance of Chromosomes (SMC) complexes and cell cycle kinases, particularly Polo-like (PLK) kinases and Aurora kinases. The Jordan lab uuse mouse as a model organism to study consequences of gene mutation and chromosome missegregation, which give rise to physical and mental developmental defects, infertility and cancer predisposition. They also use mouse and human pluripotent stem cells to help define the function of these proteins within essential molecular pathways of the cell. 

Current research from the Jordan laboratory encompasses the following:

1) Gametogenesis (spermatogenesis and oogenesis)

2) Pluripotent stem cell preservation, proliferation, and differentiation

3) Neurodevelopment